ISHAN DURVASHA, ANİL KUMAR, SHWETA AGARWAL
Acta Pharmaceutica Sciencia - 2025;63(2):271-292
In this study, an innovation in the form of a hydrogel sheet containing Carica papaya seed extract was developed and assessed for wound healing activity. The hydrogel sheet was prepared by using sodium alginate, guar gum, glycerol, methyl, and propyl paraben as excipients. Ninehydrogel formulations were prepared by varying the amount of sodium alginate (1.5%, 2.5%, and 3.5%), extract (8%, 10%, and 12%), and guar gum (0.8%, 1.2%, and 1.5%). The formulations prepared were evaluated for physicochemical characteristics like colour, pH, weight variations, folding endurance, tensile strength. Surface characteristics were studied by scanning electron microscopy. Wound healing potential was studied on wistar rats with hydrogel sheet (12%) showing 97.5% wound closure. All hydrogels containing seed extracts showed superior healing performance vis-a-vis control hydrogel. It can be deduced from the in vivo evaluation that the Carica papaya seed extract hydrogel sheet has wound healing properties comparable to the marketed hydrogel sheet.
