Ng Xiang YIN, Eyrique Goh Boay HEONG, Adrian Teoh Zen YI, Ong Shir LEE, Suryasmi DUSKI
Ulus Medical Journal - 2026;4(1):1-6
Fibroblastic reticular cell tumour (FRCT) is an exceptionally rare neoplasm arising from specialised fibroblastic reticular cells of the lymphoid stromal network. Primary involvement of bone is extraordinarily uncommon, with only isolated cases reported in the literature. We present a case of a 40-year-old woman with a destructive lesion of the proximal humerus subsequently diagnosed as FRCT. The patient was treated with neoadjuvant chemotherapy followed by wide surgical excision and endoprosthetic reconstruction. This report highlights the clinical, radiological, pathological, and therapeutic challenges associated with this rare entity and reviews emerging concepts of FRCT pathogenesis, including ectopic stromal differentiation, chemokine-driven microenvironmental mimicry, and mismatch-repair deficiency. This case contributes to the limited body of literature on primary osseous FRCT and underscores the importance of multidisciplinary management.
