Ömer CANDAR, Ömer EKİNCİ, Ali DOĞAN, Mehmet ASLAN, İbrahim ARAS, Cengiz DEMİR
Journal of Current Hematology & Oncology Research - 2026;4(3):116-119
Extranodal lymphomas, by definition, can involve any organ or tissue. Brain parenchyma, spinal cord, eyes, cranial nerves, and meninx are extranodal regions that show involvement at much lower rates. It is quite rare for lymphoma patients to present to the hospital with symptoms and findings associated with spinal cord compression as the initial presentation. This condition can lead to irreversible autonomic dysfunction, and motor and sensory loss. Here, we present a rare primary spinal intradural extramedullary diffuse large B-cell lymphoma (DLBCL) case who presented with acute neurological symptoms and no findings of cerebral involvement or involvement at any other site. Magnetic resonance imaging (MRI) was performed for the spinal region. Surgical procedure was performed for the detected mass. Immunohistochemical staining of the excised mass was performed. In the surgical operation, the mass showed partial invasion of the vertebral bone and the surrounding muscle. Considering the rapid progression of the neurological deficit, surgical resection was performed primarily for spinal decompression. Subsequently, 6 courses of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy regimen were given for the residual tissue, and radiotherapy was administered to the involved region. Timely and effective treatment achieved a complete recovery of motor and sensory function. The patient remains in complete remission without clinical or radiological relapse under follow-up after nearly 4 years. Although it is a rare condition, primary spinal intradural extramedullary DLBCL disease should be suspected in patients who present with acute neurological symptoms and have no signs of cerebral involvement or involvement elsewhere, and necessary investigations should be performed by paying attention to this.
