HAYAL UZELLİ ŞİMŞEK
The Journal of European Internal Medicine Professionals - 2025;3(2):71-77
Background: The regenerative capacity of the endometrium is attributed to stem/progenitor cells. Despite their remarkable regenerative capacity, in some cases, impairments in regeneration can be observed. Endometrial mitochondria transplantation into the uterine cavity improves the uterine environment in Asherman’s syndrome. Mitochondria transfer shows therapeutic advantages by supporting tissue metabolism and viability. However, the disruptive environment of the endometrium could affect mitochondrial health adversely. Increasing mitochondrial activity with progestin protects against apoptosis. The aim was to investigate the effect of progestin supplementation during exogenous mitochondrial transplantation. The study was designed as an in vitro cell culture of endometrial stromal cells. Mitochondria were isolated from the same cell line, representing autologous mitochondria transplantation.
