Ahmet Kayahan TEKNECİ, Hasan YAVUZ, Gizem KEÇECİ ÖZGÜR, Tevfik İlker AKÇAM, Ayşe Gül ERGÖNÜL, Kutsal TURHAN, Alpaslan ÇAKAN, Ufuk ÇAĞIRICI
Türk Göğüs Kalp Damar Cerrahisi Dergisi - 2026;34(2):192-197
Background: To investigate prognostic significance of systemic inflammation-related parameters in patients undergoing cytoreductive surgery and hyperthermic intrathoracic chemotherapy for malignant pleural mesothelioma (MPM). Methods: Data from 55 patients were analyzed retrospectively. Demographic characteristics, survival outcomes and inflammation-related parameters (neutrophil/lymphocyte ratio [NLR], platelet/lymphocyte ratio [PLR], lymphocyte/monocyte ratio [LMR] and pan-immune inflammation value [PIV]) were evaluated. Results: Overall survival (OS) was 61.26+/-13.03 (3-79) months in patients with low NLR, whereas, it was 23.18+/-3.53 (1-147) months in patients with high NLR (p=0.012). No statistically significant differences in OS were detected according to LMR, PLR and PIV. In addition, OS was 24.40+/-4.91 (3-92) months in men and 52.8+/-10.92 (1-147) months in women (p=0.031). Conclusion: In this study, NLR was found to be associated with survival in agreement with the existing literature, thereby distinguishing it from other inflammatory markers as a prognostic factor. In clinical practice, predicting patient prognosis based on pre-treatment NLR may provide a valuable guidance for treatment decision-making.
