Hanife Seda MAVİLİ, Ömer ATMIŞ, Fatma Seher PEHLİVAN, Fatma Sezen ÇAVDAROĞLU DEVECİ, Ali Rıza KANDİLOĞLU
Turkish Journal of Medical Sciences - 2026;56(2):541-553
Background/aim: Tumor budding (TB) and poorly differentiated clusters (PDCs) are histopathological parameters that have been associated with poor prognosis in various malignancies, particularly colorectal carcinoma. Although numerous studies have demonstrated an association between the microcystic, elongated, and fragmented (MELF) pattern in endometrial carcinomas and lymphovascular invasion as well as lymph node metastasis, the literature regarding TB and PDCs in this context remains limited. This study aimed to investigate the potential associations of the MELF pattern, TB, and PDCs with overall survival, progression-free survival, and clinicopathological parameters in cases of endometrioid endometrial carcinoma (EEC).
