Melis KILINÇ, Mehmet UZUN, İlkay Tuğba ÜNEK
Forbes Tıp Dergisi - 2026;7(1):1-6
Objective: Gastric cancer continues to be a pressing issue in global health. This research seeks to examine the relationship between immune system-related inflammatory markers. Methods: The research involved 184 cases of locally advanced gastric cancer diagnosed between January 2010 and January 2021. In light of its retrospective methodology, the study did not necessitate informed consent, as per institutional ethical guidelines. Receiver operating characteristic analysis was applied to establish the optimal threshold values for the systemic inflammatory response index (SIRI), systemic inflammatory index (SII), prognostic nutritional index (PNI), pan-immune inflammation value (PIV), neutrophil-lymphocyte ratio, lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS). In these groups, survival outcomes were analyzed using the Kaplan-Meier method. The association between mortality and risk factors was assessed using Cox regression analysis. All tests were deemed statistically significant if the p<0.05. Results: The SIRI, SII, PIV, PNI, LNR and LODDS values were shown to be correlated with overall survival (OS) duration (p<0.05). Cox regression model with multiple variables identified that PNI was an independent determinant of OS (p=0.045). Conclusion: The conclusions drawn from this research suggest that immune-inflammation markers, along with the LNR and LODDS values of patients with local advanced stage gastric cancer diagnosis may be used as prognostic factors in routine clinical practice. Detection of these immune-inflammation markers, LNR and LODDS values may guide clinicians in prognostic evaluation as well as the creation of personalized treatment approaches.
