ADEM DELİGONUL, NİLUFER AVCİ, MERAL KURTUL, SEBNEM OZEMRİ SAG, OZGEN ISİK, MERVE HAFİZOGLU, EMRE HAFİZOGLU, BİROL OCAK, AHMET BİLGEHAN SAHİN, SİBEL OYUCU ORHAN, ERDEM CUBUKCU, TURKKAN EVRENSEL
Eurasian Journal of Medical Investigation - 2021;5(1):62-66
Objectives: Microsatellite instability (MSI) a form of pervasive erratic expansion of microsatellites can be identified in 15?20% of all patients with sporadic colorectal cancer (CRC). To gain further insight into the prognostic value of MSI in CRC, we sought to investigate this issue in a nonselected sample of Turkish patients seen in daily practice and to establish whether the MSI status is associated with survival outcomes. We specifically focused on patients with stage 2 and stage 3 CRC because they are a heterogeneous group in need of an improved clinical management. Methods: A total of 81 patients were enrolled into the study. MSI analysis was performed a dedicated platform and classified into three types, as follows: microsatellite stability (MSS), low microsatellite instability (MSI-L), and high microsatellite instability (MSI-H). Disease-free survival (DFS) and overall survival (OS) served as the main outcome measures. Results: Patients with MSI-H had a significantly higher frequency of right colon tumors compared with those with MSI-L/MSS. Moreover, no cases of rectal tumor were observed in the former group (p=0.002). As a result, the use of radiotherapy was limited to patients with MSI-L/MSS (p=0.02). Patients with MSI-H did not differ from those with MSI-L/ MSS both in terms of DFS and OS. Conclusion: Our study demonstrates that Turkish patients with proximal colon cancer more frequently have MSI-H compared to those with distal colon cancer. However, the MSI status did not have a significant impact on survival outcomes.
