Yalcin YERHAN, Murat ISPIROGLU, Nurten Seringec AKKECECI, Kadir GISI, Bulent KANTARCEKEN
Laparoscopic Endoscopic Surgical Science - 2026;33(1):1-6
Introduction: A novel index called the pan-immune inflammation value (PIV) reflects the body's systemic inflammation and immunological response. This study aimed to determine whether the PIV can be used as a diagnostic biomarker in assessing disease activity in patients with ulcerative colitis (UC). Materials and Methods: According to the Truelove and Witts criteria, this retrospective study included 64 clinically active UC patients and 64 UC patients in remission. For the differential diagnosis of active UC patients from patients in remission, the cut-off value was estimated by making receiver-operator curves (ROC) of PIV, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR). Results: There were no significant differences between the active UC patients and UC patients in remission regarding demographic characteristics such as age and gender. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), NLR, PLR, and PIV were significantly elevated in active UC patients than those in remission (p<0.001). According to ROC curve analysis, PIV had the greatest predictive accuracy for active UC (358.37 was the optimal PIV cut-off for active UC) with specificity and sensitivity of 71.9% and 73.4%, respectively (AUC:0.821, p<0.001). Conclusions: PIV can be accepted as a promising marker that contributes to the evaluation of disease activation/remission and severity for ulcerative colitis.
