HALE ÇETİN ARSLAN, NEVİN YILMAZ, KADİR ARSLAN
Comprehensive Medicine - 2025;17(2):124-129
INTRODUCTION: The study aimed to determine the role of the systemic immune-inflammation index (SII) on prognosis and its cut-off value in early- and late-onset preeclampsia. METHODS: The retrospectively designed study was conducted with 195 women diagnosed with preeclampsia. The study group was divided into 92 patients with early-onset preeclampsia and 103 patients with late-onset preeclampsia. Demographic and clinical data; leukocyte, platelet, neutrophil, monocyte, and lymphocyte values; neutrophil-lymphocyte ratio (NLR); platelet-lymphocyte ratio (PLR); monocyte-lymphocyte ratio (MLR); and systemic immune-inflammation index (SII) parameters were recorded. Perinatal mortality was considered an unfavorable prognostic criterion, and its relationship with inflammatory markers was compared in two groups according to the groups’ prognosis. Results: The parameters of leukocyte, platelet, monocyte, neutrophil, lymphocyte, MLR, NLR, PLR, and SII measured at the time of diagnosis were not sig-nificant in early- and late-onset preeclampsia. However, PLR and SII values were significantly higher in the non-survivor group of early-onset preeclampsia (p=0.04, p=0.045, respectively). The ROC curve analyzed that the cut-off point for SII ≥1050.8 was 0.645 (95% CI: 0.4930.796), and for PLR ≥146.7, it was 0.648 (0.4990.797). Multiple logistic regression analysis revealed that SII and PLR were not independent predictors of adverse prognosis (p=0.829, p=0.534). DISCUSSION AND CONCLUSION: Conclusion: High PLR and SII values were not statistically significant in predicting perinatal mortality in early-onset preeclampsia. However, with the support of more comprehensive studies and examination of other practical factors as adverse prognostic criteria, the contribution of inflammatory markers in managing early- and late-onset preeclampsia may provide clinicians with a different approach to determining prognosis.
