Serpil SAVAŞ, Ayşegül Garip HONAMLIOĞLU, Adnan KARAİBRAHİMOĞLU, Serpil DEMİRCİ
Turkish Journal of Physical Medicine and Rehabilitation - 2026;72(3):329-338
Objectives: Certain symptoms of neuropathic pain and their combinations respond differently to various treatments. The Neuropathic Pain Symptom Inventory (NPSI) performs sensory phenotyping, providing a detailed assessment of neuropathic pain qualities, demonstrating responsiveness to changes in pain, and classifying patients for clinical trials in both central and peripheral conditions. This study aimed to perform a psychometric validation of the Turkish version of the NPSI (NPSI-T). Patients and Methods: In this cross-sectional study, the NPSI-T, Douleur Neuropathique 4, and Numeric Rating Scale were administered twice to 275 patients with central and peripheral neuropathic pain (PNP) at 1-week intervals. All reliability and validity analyses, including factor analyses, Cronbach's alpha, Hotelling's T2, Tukey's test of nonadditivity, and item analysis, were performed using SPSS 27.0 (IBM Corp., Armonk, NY , USA). Software to compute descriptive statistics. Results: The NPSI-T showed high reliability with a Cronbach's alpha of 0.89, an internal consistency Spearman-Brown coefficient of 0.779, and a significant 27% difference between upper and lower groups. The total explained variance was 61.58%, and five subdimensions were identified through exploratory factor analysis. Confirmatory factor analysis confirmed that the structure, consisting of four subdimensions with 9 items, is valid, as indicated by excellent goodness-of-fit indices. Conclusion: The results of this study indicate that the NPSI-T is a reliable and valid instrument for assessing Turkish patients with central and PNP syndromes.
