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RECURRENCE OF PROTEINURIA AFTER CESSATION OF TOCILIZUMAB IN PATIENTS WITH AA AMYLOIDOSIS SECONDARY TO FMF

SEDAT YILMAZ, EMRE TEKGÖZ, MUHAMMET ÇINAR

European Journal of Rheumatology - 2018;5(4):278-280

Division of Rheumatology, Department of Internal Medicine, Health Sciences University Gülhane School of Medicine, Ankara, Turkey

 

There is no established treatment protocol for amyloid-A (AA) amyloidosis secondary to Familial Mediterranean Fever (FMF). Recently, we reported the efficacy of tocilizumab in 11 amyloidosis cases associated with FMF. In 2 patients of 11, we discontinued the tocilizumab administeration owing to the normalization of amyloidosis-related symptoms, but proteinuria re-occurred eventually. Fortunately, the patients responded to tocilizumab re-treatment. This led us to conclude that physicians should not stop the treatment, even in patients with normalized proteinuria levels.