FATMA KUBRA TOMBULTURK, HURİ DEDEAKAYOGULLARİ DEMİRCİ, HURİ DEDEAKAYOGULLARİ DEMİRCİ
International Journal of Medical Biochemistry - 2025;8(2):89-98
Objectives: Hyperglycemia, one of the most important metabolic indicators of diabetes, causes increased oxidative stress and inflammation both systemically and locally at the tissue level, particularly in chronic wound sites where healing is impaired. Increased oxidative stress products are controlled by the body’s antioxidant capacity. Oxidative damage develops as a result of excessive production or improper quenching of reactive oxygen species (ROS) and is an important cause of non-healing chronic wounds. We aimed to accelerate wound healing by increasing the antioxidant capacity of oxidative damage caused by diabetes by applying metformin, which is routinely used orally, topically on wounds
