Emre Burakhan AKAY, Sevgi KULAKLI, Özge AYDIN
Türkderm-Türk Deri Hastalıkları ve Frengi Arşivi - 2026;60(1):44-46
Jessner's lymphocytic infiltration (JLI) is an uncommon, chronic, benign T-cell dermatosis first reported by Jessner and Kanof in 1953. It manifests as infiltrated erythematous papules and plaques that favor the face, neck, and upper trunk. Although many lesions persist for months and can regress without scarring, relapse is common. The etiology remains elusive, and proposed triggers include autoimmunity, genetic susceptibility, infectious agents, and drug exposure. Current therapy usually consists of topical or intralesional corticosteroids and systemic antimalarials; however, the clinical benefit is frequently limited. We describe a refractory case that achieved rapid and durable remission with low-dose methotrexate (MTX), underscoring its value in difficult-to-treat JLI.
