Ilyas OZTURK, Ibrahim Halil BILEN, Orcun ALTUNOREN
Van Medical Journal - 2026;33(1):97-103
Introduction: Several inflammatory markers are thought to be potential predictors of disease progression and mortality in end-stage renal disease. In the present study, we aimed to assess the potential association between newly described inflammatory markers immature granulocyte (IG), delta neutrophil index (DNI), and systemic immune-inflammation index (SIII) and arterial stiffness (AS) in hemodialysis (HD) patients. Materials and Methods: Medical records of HD patients undergoing outpatient clinic were retrospectively reviewed. A single-cuff arteriograph device was used to measure AS. IG and DNI levels were determined using a specific automated hematology analyzer. SIII was calculated using the formula: (neutrophil count x platelet count) / lymphocyte count. Results: A total of 117 patients were enrolled, with a mean age of 53.6+/-14.5 years; 55.6% were male and 44.4% were female. Correlation analysis showed that pulse wave velocity (PWV) was strongly correlated with age, body mass index, and systolic blood pressure; positively correlated with IG and DNI; and negatively correlated with serum albumin levels. When the effect of age was eliminated in the partial correlation analysis, the relationship between PWV and inflammation markers disappeared. Regression analysis revealed that the most important determinants of PWV were age and systolic blood pressure (SBP). Conclusion: In HD patients, the relationship between PWV and IG & DNI is mediated by age, but there is no relationship between PWV and SIII. While these routinely obtainable hematological parameters cannot be directly used for cardiovascular risk assessment in this population, they can provide insights into patients at risk.
