ORHAN KAYAKIRAN, SUAT KONUK, EMİNE ÖZSARI
Annals of Clinical and Analytical Medicine - 2024;15(11):799-802
Aim: In this study, we aimed to investigate the relationship between Total IgE levels obtained during follow-up of asthma patients receiving moderate to high dose inhaled corticosteroid therapy with a pre-diagnosis of lower respiratory tract infection, and post-treatment, with infective parameters, hospitalization, and frequency of attacks. Material and methods: Retrospective analysis was conducted on 132 patients diagnosed with asthma, despite the use of moderate to high dose inhaled steroids, based on their medical history, pulmonary function tests, and laboratory investigations. Results: The frequency of Total IgE levels being 100 or higher in patients hospitalized in the last year and the frequency of decrease in Total IgE levels with a decrease in CRP levels were statistically significantly higher among the patients included in the study. In conclusion, the frequency of attacks and hospitalizations was statistically significant in patients with variable Total IgE levels. Discussion: We observed statistically significant increase in Total IgE levels in patients followed with a preliminary diagnosis of lower respiratory tract infection. Additionally, a significant correlation was observed between elevated Total IgE levels and patients who experienced exacerbations within a year and those hospitalized due to asthma attacks. This suggests that Total IgE may be valuable both in predicting the severity of the disease and in assessing the risk of exacerbation within a year in asthma patients. Furthermore, the data in our study suggest that serum Total IgE levels may be valuable as a biomarker in patients with Asthma-COPD overlap.
