Ali Amca, Elvan Evrim Tuna, Melih Cayonu, Zehra Betül Paksoy
The Turkish Journal of Ear Nose and Throat - 2025;35(3):149-154
Objectiv e: This study aimed t o in v estig at e the a s sociation between serum infl ammat ory mark er s, p artic0ul arl y the S y st emic Immune0Infl ammat ory Inde x (SII), and dise a se se v erit y and olf act ory function in p atients with chr onic rhinosinusitis (CR S). Mat eria ls and Methods: A t ot a l of 5 9 CR S p atients and 2 9 he a lth y c ontr ols wer e included. P atients wer e c at eg orised a s CR SsNP (n= 30) or CR SwNP (n=2 9). Olf act ory function w a s a s ses sed with the Sniffin ' Stick s t est , wher e a s dise a se se v erit y w a s e v a luat ed using the L und-K ennedy endosc opic and L und-Mack a y r adiol ogic a l st a ging s y st ems. Qua lit y of lif e w a s me a sur ed using the SNO T 0 22 questionnair e . Infl ammat ory indic es, including NLR, PLR, ELR, and SII, a s well a s eosinophil c ounts and t ot a l serum IgE l e v els, wer e ana l y sed. R esults: C omp ar ed with c ontr ols, CR SwNP p atients demonstr at ed signific ant l y higher eosinophil c ounts and ELR v a lues (p<0. 00 1). No signific ant diff er enc es wer e observ ed f or IgE, NLR, PLR, or SII l e v els between the gr oups (p=0.2 48). Olf act ory sc or es showed a signific ant neg ativ e c orr el ation with both r adiol ogic a l and endosc opic st a ging. Import ant l y , s y st emic infl ammat ory indic es such a s SII and NLR wer e not a s sociat ed with olf act ory dy sfunction, sugg esting their limit ed dia gnostic utilit y in CR S. C onclusion: Whil e most s y st emic infl ammat ory indic es did not c orr el at e with olf act ory perf ormanc e or dise a se se v erit y , ELR and eosinophil c ounts wer e mark edl y el e v at ed in p atients with CR SwNP , highlighting the pot entia l dise a se0specific r el e v anc e of ELR in CR S0r el at ed olf act ory dy sfunction.
