Eda ÇEKER
The Journal of European Internal Medicine Professionals - 2026;4(1):13-20
Background: This study aimed to examine the frequency and clinical characteristics of kidney dysfunction at the time of multiple myeloma (MM) diagnosis, focusing on factors associated with MM-related nephropathy, to identify factors associated with renal recovery among patients presenting with impaired kidney function. Methods: This retrospective single-center study included patients diagnosed with MM between 1999 and 2009. Of 204 screened patients, 136 were eligible for analysis. Kidney dysfunction was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² at diagnosis. Results: Kidney dysfunction was present in 24 patients (17.6%) at diagnosis. Compared with those with preserved renal function, these patients had higher rates of light chain myeloma, higher beta2-microglobulin and CRP levels, and greater proteinuria (all p <= 0.05). Renal ultrasonography abnormalities were significantly more common in the kidney dysfunction group (p < 0.001). Among patients with kidney dysfunction, renal recovery occurred in 9 of 24 (37.5%). Conclusion: Kidney dysfunction at diagnosis in MM patients is associated with advanced disease stage, and unfavorable laboratory and clinical features. These findings underscore the importance of early recognition and appropriate management of renal impairment in MM.
