GÜL ÖZHAN, H ARZU ERGEN, BUKET ALPERTUNGA, TURGAY İSBİR
Advances in Molecular Medicine - 2006;2(4):175-179
Background: Several studies have evaluated the possible association between intakes of antioxidant micronutrients, such as retinol, a-tocopherol, and prostate cancer risk, but the evidence is stil inconsistent. The present study was undertaken to investigate the relationship between serum retinol and a-tocopherol levels and prostate cancer risk. Methods: Serum antioxidant levels were assayed in 36 patients with prostate cancer and 36 control by high-performance liquid chromatography (HPLC). Results: For a-tocopherol was the findings statistically significant (OR: 1.87; 95% CI 0.3 - 0.35; P: 0.017) while there was no statistically significant association between serum retinol levels and prostate cancer risk (OR: 0.62; 95% CI -0.31 - 0.50; P: 0.603). Also, we examined the association among smoking, family history of cancer and prostate cancer risk. There was statistically a low significant association between smoking and prostate cancer risk, a high significant association between family history and prostate cancer risk (OR 1.361; 95% CI 0.49-3.76 and OR 13.43; 95% CI 2.72-66.33, respectively). Conclusion: Our findings provide additional support for the association among smoking, levels of antioxidant micronutrients and cancer insidens
