Betül Akgün Aktaş, Emre Gençaslan, Ezgi Başaran, Ayşe Altındiş Bal, Burcu Bozkurt Özdal, Fatma Doğa Öcal, Dilek Şahin
Journal of Health Sciences and Medicine - 2025;8(6):1124-1128
Aims: To compare first trimester serum inflammatory markers in obese pregnant women with healthy pregnant women and to investigate the predictive value of these markers for pregnancy and neonatal outcomes Methods: This prospective observational study included 46 pregnant women with maternal obesity and 60 healthy pregnant women without obesity. The demographic characteristics, obstetric and neonatal outcomes of the participants were evaluated, and the neutrophil-lymphocyte ratio (NLR), systemic inflammation index (SII: NLR*platelet), systemic inflammation response index (SIRI: NLR*monocyte), aggregate index of systemic inflammation (AISI: NLR*platelet count*monocyte), and PLR (platelet-lymphocyte ratio) were calculated. To evaluate the predictive value for neonatal intensive care unit (NICU) admission and adverse obstetric outcomes, receiver operating characteristic curves were generated and the area under the curve values were calculated. Results: The demographic characteristics of both groups were similar. In the study group, adverse obstetric outcomes, and NICU requirement were increased. In the maternal obese group, inflammatory markers such as SII, SIRI, AISI, and NLR were significantly elevated. PLR was also increased in the study group. In ROC analysis, it was found that the levels of inflammatory markers to predict adverse obstetric and neonatal outcomes in obese pregnant women were statistically significant. Conclusion: SII, SIRI, AISI, PLR, and NLR may be helpful in predicting neonatal and obstetric outcomes in maternal obesity.
