BİRKAN BİRBEN, GÖKHAN AKKURT, TUGAN TEZCANER, EDA ÖZTURAN ÖZER, FİRDEVS ZEYNEP TAŞTEPE, FEZA KARAKAYALI, GÖKHAN MORAY
Medical Journal of Islamic World Academy of Sciences - 2020;28(1):12-17
This study aimed to evaluate the anti-inflammatory and anti-oxidant properties of propolis and its effect on the fibrinolytic system in postoperative adhesions. The rats were randomly divided into 3 groups of 10, and a modified cecal abrasion model was created. Group 1 was the sham group. Group 2 received 0.4 mL of ethanol (96%), while Group 3 was administered 0.4 mL of propolis (900 mg/kg) and ethanol (96%) solution intraperitoneally. The adhesions were evaluated macroscopically and microscopically. The adhesion in the propolis group was significantly higher according to the scores of Nair (ethanolpropolis P > 0.002 and shampropolis, P > 0.023) and Zühlke (ethanolpropolis P > 0.033 and shampropolis P > 0.024). Propolis administration was significantly associated with increased fibrosis (P > 0.01) and vascular proliferation (P > 0.01). The increase in peritoneal adhesion in the propolis group might have been due to propolis being retained in the abdomen longer than normal and the higher concentration of the solvent.
