SERKAN KARAHAN, ERTUĞRUL OKUYAN
Experimental and Applied Medical Science - 2021;2(3):189-196
Pulmonary embolism is a thromboembolic disease with high morbidity and mortality rates. Ratio of Monocyte-to-HDL cholesterol (MHR) could be present the inflammatory status of patients. The aim of this study was to research the association of MHR, which is a new marker in predicting the prognosis of patients with pulmonary embolism. Patients who were followed up in our hospital with the diagnosis of pulmonary embolism between October 2016 and June 2020 were included in the study. Patients’ demographic data such as age and gender, vital findings, comorbid diseases, lipid profiles, renal function tests, hemogram outcomes at admission, electrolyte values and cardiac markers were recorded and analyzed. Patients’ pulmonary embolism (PE) clinical classes were determined. The correlations between monocyte/HDL-cholesterol ratio and PE severity were analyzed. A total of 160 patients followed up in our hospital due to PE were included in the study. Of all patients 38.2% (n=60) were diagnosed with massive and 61.8% (n=100) non-massive PE. There were statistically differences between Non-massive and massive PE in terms of Chronic renal failure, Troponin, D-dimer, HDL, creatinine, White Blood Cell, Monocytes, Monocytes/ HDL ratio, sPAB and Survive status (p=0.035, p=0.004, p=0.046, p=0.000, p=0.008, p=0.031, p=0.001, p=0.000, p=0.000, and p=0.000, respectively). There was a positive correlation between PE severity and Chronic renal failure, Troponin, D-dimer, HDL, creatinine, White Blood Cell, Monocytes, MHR, sPAB and Survive status. Of all patients included in this study, 43 patients (71.2%) died in the massive group and 16 patients (15.5%) were died in the nonmassive group. However, MHR was higher in patients who died (0.092±0.17) compare to survivor (0.015±0.00) (p=0.000). Monocyte-to-HDL-cholesterol ratio, which is an inexpensive marker easily available in all centers, can be used in acute pulmonary embolism for PE severity status and mortality status.
