Ebu Bekir Sıddık YILMAZ, Serenat ERİŞ YALÇIN
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi - 2026;33(1):87-92
Objective: To assess whether routine viral and autoimmune hepatitis tests and hepatobiliary ultrasonography aid in diagnosing and managing intrahepatic cholestasis of pregnancy. Material and Method: This retrospective study reviewed 120 pregnant women diagnosed with ICP at a tertiary care center from 2020 to 2025. Demographic, clinical, and laboratory data-including viral (HBsAg, Anti-HCV, Anti-HIV, CMV, EBV), autoimmune (ANA, SMA, AMA, Anti-LKM), and ultrasonographic findings-were analyzed to evaluate their role in diagnosis and treatment planning. Results: The mean age and BMI of patients were 29.6 +/- 5.3 years and 29.3 +/- 5.5 kg/m², respectively. The mean gestational week at diagnosis was 32.5 +/- 4.2, and the mean delivery week was 36.3 +/- 2.1. HBsAg positivity was observed in 0.83% of patients, while no cases were positive for Anti-HCV or Anti-HIV. Autoimmune markers were completely negative. Abnormal ultrasound findings were detected in 31.8% of patients, most commonly gallstones and grade 1 hepatic steatosis. However, these did not result in changes in clinical management. Conclusion: Routine testing for viral and autoimmune hepatitis markers and hepatobiliary ultrasound in ICP patients offers limited diagnostic benefit and seldom affects treatment decisions. These findings support a more targeted and cost-effective strategy, reserving additional tests for atypical cases or patients with treatment resistance.
