Nelson Antonio MILANÉS-GONZÁLEZ, Jose Enrique VELÁZQUEZ-AMADOR, Luis Alejandro CARRILLO-SANTILLÁN, Maria Pamela CONTLA-ARMENGOL, Eder Fernando RÍOS-BRACAMONTES
Cyprus Journal of Medical Sciences - 2026;11(3):231-233
Wyburn-Mason syndrome (WMS) is an extremely rare, non-hereditary congenital disorder characterized by arteriovenous malformations (AVMs) that primarily affect the retina and central nervous system and, less commonly, other structures. Its clinical presentation is highly variable, and management is often challenging due to the high risk of morbidity and mortality, particularly in deep lesions that are not amenable to surgical, endovascular, or radiosurgical treatment. We present the case of a young woman with relevant neurologic and ophthalmologic history who developed a massive subarachnoid hemorrhage secondary to rupture of a basilar artery aneurysm associated with a prepontine AVM, a complication that is poorly documented in the literature. The clinical course and fatal outcome are described. This case highlights the severe neurological complications associated with WMS and underscores the importance of early recognition and long-term monitoring in patients with high-risk vascular malformations.
