M.V. CHEBOTAREVA, K.A. NIKOLSKAYA, D.N. ANDREEV, S.G. KHOMERIKI, D.S. BORDIN
Caucasian Medical Journal - 2026;4(2):65-65
Background: The data on the role of serum pepsinogens in detecting atrophic gastritis are conflicting. ?bjective: To evaluate the accuracy of pepsinogen (PG) I and pepsinogen II for the detection and staging of atrophy. Materials and methods: 237 patients (56 men and 181 women) were examined. All respondents underwent a 13C-UBT, a blood pepsinogens and antibodies to gastric parietal cells. 13C-UBT positivity was defined as a DOB value >= 4%. Serological markers of atrophy were PGI<=30mug/l and PGI/PGII<=3. EGD with a biopsy of the gastric mucosa from 5 standard points according to the Sydney system and a morphological study according to the OLGA system. Results: H. pylori -associated gastritis was present in 135 patients, of whom 13 had severe atrophy (OLGA stages III-IV). Autoimmune gastritis (AIG) was diagnosed in 47 patients, of whom 34 had severe atrophy. AIG & H. pylori gastritis was present in 55 patients, of whom 13 had severe atrophy. Sensitivity and specificity of pepsinogens by gastritis etiology are shown in Table 1. Conclusion: Serum pepsinogens showed the higher diagnostic accuracy in autoimmune gastritis (due to corpus involvement) and the lower in H. pylori -associated gastritis (likely due to isolated antral lesions).
