CİGDEM YAYLA ABIDE, ENİS OZKAYA, SEMRA KAYATAS ESER, BELGİN DEVRANOGLU, BULENT EMRE BILGIC, TAYFUN KUTLU
Gynecology Obstetrics & Reproductive Medicine - 2018;24(2):87-91
OBJECTIVE: We aimed to assess the effect of serum albumin level adjusted progesterone levels on the trigger day on clinical pregnancy rate in intracytoplasmic sperm injection cycles. STUDY DESIGN: A total of 100 women undergoing intracytoplasmic sperm injection cycles due to poor ovarian reserve or tubal factor infertility were included in this study. Serum progesterone and albumin levels on the trigger day were utilized to predict clinical pregnancy among normal and poor responders. RESULTS: There were significant differences between groups with and without successful clinical pregnancy in terms of serum albumin (4.6 vs. 4.3 g/dL), progesterone levels (0.5 ng/mL vs. 0.7 ng/mL) on the trigger day and endometrial thickness (11.5 mm vs. 9.3 mm) (p<0.05, p<0.05 and p<0.05, respectively). In ROC analyses, progesterone level on the trigger day was found to be a significant predictor of clinical pregnancy (AUC=0.652, p=0.015). An optimal cut-off value of 0.55 ng/mL was obtained with 65% sensitivity and 57% specificity. However, after adjustment for progesterone and albumin levels, endometrial thickness was found to be significantly associated with successful clinical pregnancy (β=0.39, sig=0.038). CONCLUSION: Progesterone action may be altered by albumin concentration, therefore albumin concentration should be taken into account to determine a cut off for premature progesterone rise.
