Bandar Ibrahim AAYF AL-SHAMMARI, Rojan Ghanim MOHAMMED AL-ALLAFF
Asthma Allergy Immunology - 2025;23(3):251-262
Objective: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterised by immune dysregulation. Fc epsilon receptor I (FcepsilonRI) plays a crucial role in AD pathogenesis by mediating IgE-dependent immune responses. This study aimed to investigate the role of free FcepsilonRI in serum and its impact on white blood cell subsets in patients with AD. Materials and Methods: A total of 110 AD patients aged 1-30 years were recruited from hospitals in Mosul between October 2024 and February 2025. Participants were divided into two age groups: children (1-15 years, n = 38) and adults (16-30 years, n = 32), with age-matched healthy controls (n = 40). Blood samples were analysed for FcepsilonRI levels using enzyme-linked immunosorbent assay and for white blood cell counts via CBC analysis. Results: FcepsilonRI levels were significantly higher in AD patients compared to controls (P <= 0.05), with children exhibiting higher concentrations than adults. Regression analysis revealed significant correlations between FcepsilonRI levels and white blood cell subpopulations, including neutrophils, lymphocytes, and eosinophils. Conclusion: These findings suggest that FcepsilonRI contributes to the inflammatory profile of AD, with potential implications for autoimmune disease development. FcepsilonRI may serve as a valuable biomarker for AD severity and immune dysregulation. Future studies should explore its therapeutic targeting to mitigate chronic inflammation in AD patients.
