Zaid Mohammed Joodi Al-Janabi, Aeshah A. Ahmed, Mays Talib Abdallah, Mustafa H. Hussien
Perinatal Journal - 2026;34(1):56-61
Psoriasis is an autoimmune condition with major immune and inflammatory reactions that cause epidermal changes. The blood molecules can show signs related to the progression or remission phase. Among those molecules are Interleukin-21 (IL-21), soluble FAS (SFAS), and soluble FAS ligand (SFASL), which are used separately to determine possible practical values. In our study, we found that these molecules are efficient for diagnosing patients with psoriasis. We used 50 patients with a plaque type of psoriasis in Iraq with a psoriasis severity level according to its Psoriasis Area and Skin Index (PASI), to which we added 50 healthy Iraqi subjects who matched the age and sex. We used blood molecules to test the values using an ELISA test to measure the values in blood molecules. We used non-parametric statistical methods to conduct our analysis. The methodology used included patients who underwent testing using PASI to which we added another category according to severity. We utilized these methods to test our data. We found that there are increased values for blood molecules (IL-21), (SFAS), (SFASL), which positively correlate with PASI values. As patients suffered more from PASI symptoms, values increased for (IL-21), (IL-21+sFas). We used an "Analysis" technique to test our values. We found that these values are completely sensitive for diagnosing patients. We identified "IL-21" to be dependent in terms of its values for describing patients' symptoms. We conclude that IL-21, SFAS, and SFASL, are related to patients' symptoms. These blood molecules are useful for diagnosing patients to whom we recommend future treatment.
