Orkun İLGEN, Sibel Ejder TEKGÜNDÜZ, Nurcan YORUK, Nazım Ozan ÇELEBİOĞLU, Berrin Göktuğ KADIOĞLU
Journal of Basic and Clinical Health Sciences - 2026;10(1):97-103
Purpose: This study aimed to investigate the association between platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and cervical squamous intraepithelial lesions. Material and methods: The institutional database was reviewed, and cases diagnosed with cervical pathology-including high-grade squamous intraepithelial lesions (HSIL) and low-grade squamous intraepithelial lesions (LSIL)-between January and December 2024 were identified. Complete blood count (CBC) results along with clinical and pathological data were collected. The relationship between NLR, PLR, MLR, SII, and cervical pathologies was assessed. Results: No significant differences were found between NLR, PLR, or MLR values across HSIL and LSIL groups. However, patients with HSIL showed significantly higher SII values compared to LSIL cases. The optimal SII cut-off value for distinguishing HSIL from LSIL was calculated as 845.10. Conclusion: These findings suggest that SII may serve as a simple and effective marker for differentiating HSIL from LSIL, in contrast to more conventional markers such as NLR, PLR, and MLR.
