Hamza AKTAŞ, Mehmet Semih ÇELİK, Yunus YAKUT, Serhat ÖZDEMİR
Medical Records - 2026;8(1):1767596-1767596
Aim: Chronic inflammation of the skin is a hallmark of seborrheic dermatitis (SD) with relapsing episodes and unknown etiology, which affects the patients' quality of life. Studies suggest that a lack of vitamins and minerals could influence the course of the disease. In this case-control study, serum vitamin D, selenium, and zinc levels of patients with SD were compared with those of a healthy control group. Material and Methods: The study included 152 patients with SD and 129 healthy controls, from whom demographic data and blood samples were collected. Disease severity was assessed using the SEDASI scoring system. Serum vitamin D and zinc levels were measured using ELISA and photometric methods, while selenium levels were also determined. Statistical analyses were performed using SPSS version 27 and JAMOVİ software, and chi-square tests were also conducted. Statistical significance was defined as p < 0.05 for all tests. Results: No significant difference in zinc levels was observed between the groups (p=0.750). However, selenium (p<0.001) and The patient group exhibited statistically significantly lower vitamin D levels (p=0.036) than the control group. Furthermore, A statistically significant negative correlation was observed between selenium levels and disease severity Conclusion: In the study, The patient and control groups showed significant differences regarding selenium and vitamin D levels. Additionally, Disease severity and selenium levels were negatively correlated. These findings highlight the need for further research regarding the potential therapeutic role of nutritional supplementation in the management of SD.
