XUEQİN MENG, BİNG YANG, DONGYA WU, TİNGTİNG PAN, FENG ZHANG, HAİYANG XİE, WENQİN XİE, XİNHUA CHEN, SHUSEN ZHENG
Experimental and Clinical Transplantation - 2023;21(11):917-920
After renal transplant, immunosuppression therapy is used to reduce the risk of rejection. Here, we describe the case of an adult living related donor renal transplant recipient with rare natural chimerism, as discovered by short tandem repeat sequence analysis. In our process of matching transplant patients, we perform human leukocyte antigen testing and short tandem repeat chimerism testing to decide posto- perative immunosuppression strategy for transplant patients. We analyzed the short tandem repeat chimerism status before renal transplant and determined that this patient represented a rare case of natural chimerism. Assessment of organ recipient chimerism can inform physicians regarding a dosage reduction of immunosuppressive agents. Short tandem repeat sequence analysis provides substantial information regarding existing polymor- phisms and can identify chimerism, if present, and thereby guide immunosuppression strategies after renal transplant, which may improve the long-term immunosup-pression-free survival of renal transplant recipients.
