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SIGNIFICANCE OF DIMINISHED HORMONE EXPRESSION IN NULLIGRAVIDA WOMAN PRESENTING WITH TRIAD OF UTERINE PATHOLOGIES

Seema Dayal, Adesh Kumar, Kalpana Kumari, Kritika Singh, Abhishek Sharma

Gulhane Medical Journal - 2025;67(4):289-292

Uttar Pradesh University of Medical Sciences, Department of Pathology, Etawah, India

 

Genital tract tuberculosis (TB) occurring together with adenomyosis and leiomyoma is rarely observed. A 40-year-old nulligravida woman was clinically diagnosed with the fibroid uterus. Histopathological examination revealed leiomyoma with adenomyosis and TB. Immunohistochemistry for oestrogen and progesterone receptors was performed to determine their expression, which was found to be moderate, although it was expected to be strongly positive. This case is being reported because of its rare coexistence of these conditions; moreover, it suggests that reduced hormone expression, particularly of oestrogen, may enhance the severity of TB, ultimately resulting in adverse reproductive outcomes.