Merve ŞİMŞEK DİLLİ, Fettah ACIBUCU, Zübeyde Şebnem AKTARAN, Şeküre Demet KÜÇÜK
Düzce Tıp Fakültesi Dergisi - 2026;28(2):252-256
Silent corticotroph pituitary neuroendocrine tumors are a rare subtype of non-functioning pituitary neuroendocrine tumors that lack the clinical and biochemical manifestations of Cushing disease. These tumors are associated with an aggressive clinical course because of a tendency for rapid progression and invasive growth, as well as a high recurrence rate. We present a 41-year-old woman without Cushingoid symptoms who presented with headache, bitemporal hemianopia, and diplopia. MRI revealed a mass extending into the suprasellar region, measuring approximately 2 x 4 cm, with internal necrotic areas and post-contrast enhancement. Following transsphenoidal resection, immunohistochemical staining demonstrated positivity for adrenocorticotropic hormone, confirming the diagnosis of a silent corticotroph pituitary neuroendocrine tumor. This case highlights the importance of recognizing silent corticotroph pituitary neuroendocrine tumors, the treatment approach, and long-term follow-up.
