Tevfik Berk Bıldacı, Can Ata, Merve Nur Çakmak, Hüseyin Aytuğ Avşar, Ufuk Atlıhan, Selçuk Erkılınç
Kocaeli Üniversitesi Sağlık Bilimleri Dergisi - 2025;11(3):97-101
Aims: Gestational diabetes mellitus (GDM) emerges during pregnancy due to physiological shifts, resulting in an adverse intrauterine environment characterized by insulin resistance and hyperglycemia, with inflammation believed to play a significant role. While inflammatory processes are typically protective, they may become dysregulated. Recognized biomarkers of inflammation include neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and lymphocyte-to-monocyte ratio (LMR). Methods: This retrospective cohort study took place between January 2022 and December 2023 at a tertiary training and research hospital. A comparison of inflammation markers was conducted between patients with (Group B) and without (Group A) GDM. Results: A total of 567 patients were included in the study. A significant difference was observed in the mean SII values between the groups, with group A exhibiting 1144+/-400 and group B having a mean SII of 1280+/-496 (p=0.002). Another significant difference observed between groups for NLR (p=0.001). Conlusion: The significant differences observed in SII values between patient groups, coupled with the discriminative abilities of SII and NLR in diagnosing GDM, underscore the potential clinical relevance of these markers.
