LAMA AL HAUSHEY
Acta Pharmaceutica Sciencia - 2024;62(2):480-496
The objective of this study was to prepare carbopol gels and to evaluate the effect of various solvents on gel spreadability and release properties of Ibuprofen (a hydrophobic compound) using screening design methodology. Five solvents of different polarities were chosen )alcohol, glycerin, PEG400, acetone, PG(. The statistical analysis of the results allowed determining the most influent solvents. Considering the whole results, it appeared that carbopol reduced spreadability while alcohol, glycerin, PEG400 and PG increased spreadability. The total released amounts of Ibuprofen were altered by both gel viscosity and Ibuprofen solubility, hence, when Ibuprofen, alcohol and acetone quantities were increased, the quantity of released Ibuprofen per cm2 inhanced. On the other hand, Carbopol, glycerin, PEG400 and PG decreased Ibuprofen release. An optimized experiment was carried out to verify the mathematical model and in order to maximize Ibuprofen release. Gel spreadability was good and enhanced Ibuprofen release was observed for the objective of relieving pain effectively.
