AHMED ABDULKADHİM HAMIDY, NOOR ALİ ABDUL JABBAR, NAWAL JASİEM SHNAWER
Acta Pharmaceutica Sciencia - 2024;62(4):814-825
Paraoxonase-1 (PON-1), it is an antioxidant enzyme that associate with highdensity lipoproteins, plays a crucial role in mitigating lipid peroxidation. Three paraoxonase forms (PON-1, 2, and 3), with PON-1 synthesized in the liver and transported with HDLs in the plasma. This study aimed to estimate the levels of paraoxonase-1, malondialdehyde (MDA), and reduced glutathione (GSH) in the sera of patients with thyroid dysfunction that include 50 patients; 25 with hypothyroidism and 25 with hyperthyroidism which compared with 25 healthy controls in a study conducted between May and July 2023, utilized the enzymelinked immunosorbent assay (ELISA) for PON-1, the thiobarbituric acid (TBA) method for MDA, and Ellman"s method for GSH which revealed that there is a significant reduction in PON-1 activity and GHS levels in both hypothyroid and hyperthyroid groups compared to controls, with a significant increase in MDA levels in the hyperthyroid and hypothyroidism groups which indicates that thyroid dysfunction influences oxidative stress markers (MDA and GSH) and PON-1 activity, which can be used as a potential biomarker for early diagnosis or as a therapeutic target for monitoring thyroid dysfunction"s clinical status.
