Hari Shankar MESHRAM, Khushboo SAXENA, Vivek KUTE, Sudeep DESAI, Sanshriti CHAUHAN
Experimental and Clinical Transplantation - 2026;24(2):119-128
Objectives: In the Indian subcontinent, data on clinical outcomes of living kidney donors remain scarce. We aimed to evaluate renal outcomes after kidney donation using estimated glomerular filtration trajectory-based analysis. Materials and Methods: In this retrospective single-center study, we analyzed 300 living kidney donors who underwent nephrectomy between January 1 and December 31, 2019, at a tertiary transplant center. Results: At median follow-up of 25.7 months, 14.3% of donors developed de novo hypertension, 9.3% developed proteinuria, and 6.0% had estimated glomerular filtration rate <60 mL/min/1.73 m2. Trajectory analysis showed a biphasic pattern of estimated glomerular filtration rate trend, characterized by an initial decline followed by stabilization after 6 to 12 months. Conclusions: In this first Indian study to use trajectory-based modeling for stratifying risk in living kidney donors after donation, kidney donation practices remain safe but also call for structured and personalized follow-up protocols for candidates with increased risk.
