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SUCCESSFUL TREATMENT OF TRANSPLANT RENAL ARTERY THROMBOSIS WITH SYSTEMIC INFUSION OF RECOMBINANT-TISSUE-PLASMINOGEN ACTIVATOR AFTER RENAL TRANSPLANT

TAKASHİ YOSHİDA, MASAAKİ YANİSHİ, TAKAHİRO NAKAMOTO, MOTOHİKO SUGİ, HİDEFUMİ KİNOSHİTA, TADASHİ MATSUDA

Experimental and Clinical Transplantation - 2017;15(5):571-573

Department of Urology and Andrology, Graduate School of Medicine, Kansai Medical University, Shin-machi, Hirakata, Osaka, Japan

 

A 24-year-old man with end-stage renal disease secondary to congenital renal hypoplasia under-went a preemptive renal transplant. Although a vascular complication occurred during surgery, the operation was completed satisfactorily. However, postoperative Doppler ultrasound showed no perfusion of the renal artery, vein, and parenchyma, indicating a transplant renal artery thrombosis. A reoperation was promptly performed, with systemic infusion of recombinanttissue- plasminogen activator during graft nephrectomy, followed by a reimplant that resulted in a salvage allograft. Immediate thrombolysis using systemically infused recombinant-tissue-plasminogen activator may be an effective treatment option for transplant renal artery thrombosis after renal transplant.