AMJAD M QANDİL, HAİTHAM N TUMAH, MOHAMMAD A HASSAN
Acta Pharmaceutica Sciencia - 2006;48(2):95-107
Two series of compounds have been synthesized and tested for their antimicrobial activity using the broth macrodilution method. Series I included N4-benzoyl-N1-dihydroxybenzoylthiosemicarbazides (3a-e) and series II included 2-benzoylamino-5-(dihydroxyphenyl)-1,3,4-thiadiazoles (4a-e) the later of which showed selectivity against Staphylococcus aureus. The most potent compound from series I was the parent compound 1 (N4-benzoyl-N1-2,5-dihydroxybenzoylthiosemicarbazide), while the most potent member in series II was compound 4c (2-benzoylamino-5-(2,6-dihydroxyphenyl)-1,3,4-thiadiazole).
