GAURAV ALANG, RUPİNDER KAUR, GURDEEP KAUR, AMRİNDER SİNGH, PANKAJ SİNGLA
Acta Pharmaceutica Sciencia - 2010;52(2):213-218
In the present study, seven new derivatives (R1 to R7) of benzothiazoles were synthesized and evaluated their anti-bacterial activity. p-toluidine on reacting with ammonium thiocynate formed 2-benzothiazolamines, which on reacted with hydrazine hydrate formed hydrazino derivative. Compounds (R1 to R7) were synthesized by reacting hydrazine derivative with different acetophenones (2‘-fluoroacetophenone, 4‘-fluoroacetophenone, 2‘-Chloroacetophenone, 4‘- Chloroacetophenone, p- Hydroxyacetophenone, 2‘- Hydroxyacetophenone, 2, 5- Dihydroxyacetophenone). All the synthesized compounds were identified by IR, NMR. The anti-bacterial activity were investigated and appreciate activity were observed.
