PRABHAKAR VERMA, VİPAN KAMBOJ
Acta Pharmaceutica Sciencia - 2010;52(4):411-415
A series of N’-[3-(4-alkayl/arylsubstituted)-4-oxo-1,3thiazolidin-2-ylidene]-2-(pyrazin-2-yloxy) acetohydrazide was synthesized by the cyclization of various N-substituted thiosemicarbazides using chloroacetic acid and sodium acetate in ethanol. Where N-substituted thiosemicarbazone prepared by the reaction of various alkayl/aryl isothiocyanate with 2-(pyrazin-2-yloxy)acetohydrazide, which was synthesized by amination of ethyl(pyrazin-2-yloxy)acetate with hydrazine hydrate. Ethyl(pyrazin-2- yloxy)acetate was prepared from the 2-hydroxypyrazine by ethylchloroacetate under reflux condition. The purity and homogeneity of compounds synthesized were determined by their sharp melting point, TLC, UV, IR, and NMR spectra. The compound N’-[3-(phenyl)-4-oxo-1,3thioazolidin-2-ylidine]-2-(pyrazin-2- yloxy)acetohydrazides, N’-(pyrazin-2-yloxy)acetohydrazide posses good antidiabetic activity with reduced toxicity.
