Ebru KUYUMCU SAVAN, Süleyman KÖYTEPE, İmren ÖZCAN, Burhan ATEŞ, Sevgi BALCIOĞLU
Anatolian Journal of Pharmaceutical Sciences - 2026;5(1):18-24
In this study, a rapid and alternative magnetic nanoparticle structure was developed for the hyperthermia treatment of cancer, a growing and significant problem. Magnetic nanoparticles hold significant potential in cancer treatment. The most important feature of magnetic nanoparticles is their ability to be targeted to tumor sites by applying an external magnetic field. Furthermore, their small size, high surface area, and the ease of control of their surface structure through surface modification are other important properties. In this study, we first synthesized nanosized, magnetically steerable CoFe2O4 nanoparticles. Subsequently, these nanoparticles were surface-modified, and the anti-carcinogenic chemotherapeutic drug methotrexate was conjugated. In the final phase of the study, chitosan was coated on the surface of the methotrexate-conjugated magnetic nanoparticle to increase biocompatibility. All structures obtained were initially characterized using FTIR and EDX spectroscopy. Furthermore, all CoFe2O4-based structures were morphologically characterized using scanning electron microscopy. This resulted in the creation of a dual-action drug structure that offers both diagnostic, monitoring, and therapeutic potential.
