JİTENDER SİNGH, PARUL GROVER, DHARAM PAL PATHAK
Acta Pharmaceutica Sciencia - 2010;52(4):511-522
In view of obtaining some potential anticonvulsant compounds we have synthesized a series of 1,2,5- trisubstituted benzimidazoles derivatives (6a-6j, 7a-7j, 8a-8j). The results of QSAR investigation and the study of various physicochemical properties indicates that the change in linker at position one (R1) does not change the activity of the synthesized compounds and optimum chain length at position two (R2) is responsible for the anti-convulsant activity. The results also showed that the synthesized compounds with electron withdrawing group at position five (R3) shows better anti-convulsant activity as predicted by QSAR studies.
