FATİH TOK, HÜMEYRA CİHANGİR, KADER ŞAN, CANSEL ÇAKIR, KÜBRA TUNA, YUSUF SICAK, MEHMET ÖZTÜRK, BEDİA KOÇYİĞİT KAYMAKÇIOĞLU
Journal of Research in Pharmacy - 2023;27(6):2416-2424
In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR, 1H-NMR, 13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC50 values of 227.84±1.48- 298.27±8.61 μM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs.
