EFE DOĞUKAN DİNCEL, GOZDE HASBAL CELIKOK, TUGBA YILMAZ OZDEN, NURAY ULUSOY GÜZELDEMİRCİ
Journal of Research in Pharmacy - 2024;28(1):155-163
Herein, we report the in vitro Acetylcholinesterase (AChE) inhibitory activities of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. The compounds were characterized by diverse spectral methods and reported by our research team previously. As a novelty we conducted in vitro AChE inhibitory activities of the title compounds and performed in silico studies to provide insight related to activity mechanism of the compounds. Compound 4f displayed the best biological activity within our compounds with 69.92% enzyme inhibition value (at a final concentration of 0.08 mg/mL) and 0.0245 mg/mL IC50 value.
