Duygu ALPASLAN, Abdullah TURAN, Tuba ERSEN DUDU, Busra MORAN BOZER, Nahit AKTAS, Mustafa TURK
Journal of Research in Pharmacy - 2026;30(4):1027-1044
In this study, p(SAO) and p(JO) organo-particles were synthesized from sweet almond oil and juniper oil via a redox polymerization method to investigate their physicochemical properties and in vitro biological activities, including antioxidant, antimicrobial, hemocompatibility, and cytotoxic effects. The structural and functional characteristics of the synthesized organo-particles were analyzed using Fourier Transform Infrared Spectroscopy (FT-IR). Particle size distribution, zeta potential, and polydispersity index were determined by dynamic light scattering (DLS), while morphological features were examined using scanning electron microscopy (SEM). The bioactivity of the organo-particles was evaluated through antioxidant, antimicrobial, and biocompatibility assays. In vitro cytotoxicity was assessed using the MTT assay on L-929 fibroblasts and Capan-1 pancreatic cancer cell lines. The results demonstrated that both p(SAO) and p(JO) increased cell viability in L-929 fibroblast cells, indicating good cytocompatibility. In contrast, p(JO) exhibited a more pronounced cytotoxic effect against Capan-1 pancreatic cancer cells, with activity comparable to doxorubicin. Moreover, combined treatment of p(JO) with doxorubicin further enhanced cytotoxic efficiency, suggesting a potential sensitizing or synergistic effect. Overall, the findings indicate that p(SAO) and particularly p(JO) organo-particles possess promising multifunctional bioactivities, including selective in vitro anticancer potential, while maintaining compatibility with normal fibroblast cells. These results suggest that p(JO) may serve as a potential candidate for further biomedical and anticancer-related investigations, pending validation through in vivo and mechanistic studies.
