MONİA HAYAZEİ, MANAR ABED, SEMRA DEMİRLİ ATICI, SHAHZAİB AHMAD, ALAA EL HUSSUNA
Turkish Journal of Colorectal Disease - 2023;33(4):92-102
Non-steroidal anti-inflammatory drugs (NSAIDs) are generally thought to be associated with an increased risk of inflammatory bowel disease (IBD) exacerbation. The aim of this systematic review is to investigate evidence on the role of NSAIDs in the exacerbation of IBD. Studies were identified by searching the electronic PubMed, EmBase, and Cochrane databases for articles published-up to December 2019. Data on patients, study methodology, study quality, trial setting (single or multicenter, secondary or tertiary center/department, country of origin), duration of follow-up, outcomes assessed, the definition of assessed outcome measures, intervention characteristics (type, dose, duration, mode of administration), and outcome measures were extracted. Due to the heterogeneity of the included studies, no data synthesis was performed. It remains unclear whether there is a consistent association between NSAID use and the risk of Crohn’s disease and ulcerative colitis exacerbation and whether NSAIDs are important in triggering IBD relapse.
