SERKAN KARAHAN, ERTUĞRUL OKUYAN
Experimental and Applied Medical Science - 2021;2(2):146-153
In this study, we aimed to evaluate the relationship between the laboratory parameters of platelet volume / lymphocyte ratio (PLR) and systemic inflammatory index (SII) with prognosis and mortality in patients with hospitalized GFR (Glomerular filtration rate) <60 ml / min and a diagnosis of acute myocardial infarction (AMI). This study was designed as a retrospective cohort study. 235 myocardial infarction (MI) patients over the age of 18 and with GFR <60 ml / min, hospitalized in our hospital between January 01, 2016 and January 01, 2019, were included in the study. The patients were divided into 2 groups as survival and mortality group. The two groups were compared in terms of demographic characteristics, clinical laboratory data (symptoms, comorbidities, laboratory findings, GFR, coronary angiography, medications and complications). Platelet lymphocyte ratio (PLR) was obtained by dividing platelet count to lymphocyte count. Systemic inflammatory index (SII) was found by multiplying neutrophil count and PLR value. The mean age of the survival group was 67.1±12,8 years. In the mortality group, the mean age was 69.55±11,1 years. PLR and SII levels were significantly higher in the mortality group compared to the survival group (p=0.002, p=0.029, respectively). According to the results of ROC analysis in mortality group patients, it was found that sensitivity 59.1% and specificity 70.4% for PLR (p=0.002); sensitivity 54.5% and specificity 60.9% for SII (p=0.029). The risk factors were found to be significantly associated with mortality in the regression analysis included PLR (β: 0.007, OR (95% CI): 1.007 (1.001 1.012), p=0.001) and SII (β: 0.001, OR (95% CI): 1.000 (0.999 1.001), p=0.041). PLR and SII were able to predict the mortality from myocardial infarction.
