Murat ŞAMBEL, Abdullah ERDOĞAN, Çağatay ÖZSOY, Şahin KILIÇ, Baran ARSLAN, Mehmet Reşat İNAL, Selim TAŞ
The New Journal of Urology - 2026;21(1):30-38
Objective: To investigate the association between serum testosterone levels and the severity of penile curvature and plaque size in men with Peyronie's disease (PD). Materials and Methods: This retrospective cross-sectional study included 108 men diagnosed with Peyronie's disease who presented to our urology outpatient clinic between January 2022 and July 2025. Results: Mean age was 59.6 +/- 7.5 years, and mean disease duration was 22.7 +/- 29.4 months. Mean horizontal and vertical curvatures were 12.1 +/- 19 derece and 28.5 +/- 19.8 derece, respectively. Mean plaque size was 8.9 +/- 7 mm. No significant differences were observed between hypogonadal and eugonadal groups in curvature severity (p>0.05), plaque size (p=0.54), or disease phase. Hypogonadal men had significantly lower SHBG and estradiol levels and higher HbA1c and triglyceride values (all p<0.05). No correlations were found between testosterone levels and curvature degree or plaque dimensions. Conclusion: Serum testosterone levels are not associated with PD severity. Hypogonadism appears to be a comorbidity rather than a determinant of disease severity, suggesting routine testosterone evaluation may not be necessary in PD management.
