ZUHAL METİN KAĞAN TUR SERKAN AKOGUL NAZİME BENSU ÖNENTAŞÇI DEMİR
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi - 2023;25(2):293-302
Objective: This study aimed to investigate the relationships between acne severity with inflammatory and metabolic markers, and their interplay. Additionally, the study sought to explore the overall activity of these markers within different inflammatory and metabolic pathways in the mechanism of acne. Material and methods: Our study was conducted as a prospective cross-sectional study with 203 patients diagnosed with acne. Acne severity was categorized into three classes: mild, moderate, and severe, according to the "International Consensus Conference on Acne Classification System". We evaluated inflammatory and metabolic markers, including fibrinogen/albumin ratio (FAR), D-dimer/albumin ratio (DAR), uric acid/HDL ratio (UHR), CRP levels, sedimentation rate (ESH), leukocyte count (WBC), vitamin D, triglyceride (TG) and HOMA-IR values in the patients. The relationships between these markers and acne severity, as well as their interrelationships, were examined. Mann-Whitney U test, Kruskal-Wallis H test, and Spearman’s correlation analysis were employed for statistical analysis. Results: It was observed that CRP (p=0.008), WBC (p=0.006) and the novel inflammatory marker UHR (p<0.001) were significantly associated with acne severity. Additionally, it is worth noting the notable impact of vitamin D deficiency on exacerbating acne severity (p=0.074). In the relationships between the markers we defined; there were significant positive correlations between ESH-CRP, ESH-FAO, ESH-HOMAIR, ESH-DAO, CRP-WBC, CRP-FAO, CRP-UHO, CRP-TG, WBC-UHO, WBC-TG, FAO-HOMAIR, FAO-DAO, HOMAIR-UHO, HOMAIR-DAO, HOMAIR-TG, UHO-TG and vitamin D-TG. Conclusion: Due to the multifactorial and complex nature of acne pathogenesis, the combined use of multiple metabolic and inflammatory markers would be more beneficial in determining severity and prognosis. Comprehensive studies are needed to develop potential new treatment methods that can target different inflammatory and metabolic pathways.
